The Nicotinic Acetylcholine Receptor (nAChR) b2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Rat antigen. The Nicotinic Acetylcholine Receptor (nAChR) b2 Antibody has been validated for the following applications: Immunocytochemistry, and Western Blot.
Description
Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits alpha4beta2, whereas alpha3beta4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, beta2-containing receptors greatly outnumber receptors that contain beta4 (McGehee & Role, 1995; Albuquerque et al., 2009), and in most brain regions, targeted deletion of the beta2 subunit virtually abolishes [3H]-epibatidine binding and receptor autoradiography (Zoli et al., 1998) due to the absence of a beta subunit required to form functional nAChRs (Champtiaux & Changeux, 2004)